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References: Sugimoto K, Murakawa Y, Sima A

PLoS ONE 9 , e97330 (2014)

More recently, Ronnie Coleman, one of the most successful bodybuilders in the history of the sport, had substantial gynecomastia that was very noticeable around his left nipple when zoomed in during his posing

Further, the inherent limitations of studying topical dosing in murine models necessitates further studies of pharmacokinetics and efficacy in larger species, as well as ocular safety and tolerability studies