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The statistical tests used in each figure are listed in the legends

ROS overproduction can contribute to epithelial injury [46], promote pro-inflammatory signaling [47], and enhance airway hyperresponsiveness

Moreover, it effectively promoted intracellular uptake, prolonged blood circulation time, and enhanced accumulation within tumor tissues

Membranes were labelled with rabbit anti-AGXT (Sigma, HPA035370, 1:1,000 dilution), mouse anti-AGXT (Santa Cruz Biotechnology, SC-517388, 1:500 dilution), rabbit anti-LDHA (Cell Signalling Technology, 2012, 1:1,000 dilution), rabbit anti-CPT1 (Abcam, ab234111, 1:1,000 dilution), rabbit anti-PPARA (Proteintech, 15540-1-AP, 1:1,000 dilution), rabbit anti-HAO1 (Abcam, 194790, 1:1,000 dilution), mouse anti--actin (Cell Signalling Technology, 3700S, 1:1,000 dilution) and mouse anti-GAPDH (Santa Cruz Biotechnology, sc365062, 1:5,000 dilution)