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Figure 1 This review summarizes current knowledge about NP, focusing on clinical conditions and probable causes, the relationship existing among oxidative stress, mitochondrial dysfunction and TRP channels activation and scientific evidence related to antioxidant supplementation

These electron-transfer pathways generate distinct electrochemical outputs, including H 2 O 2 in first-generation sensors and reduced mediator species (Med-red) in second-generation sensors, while third-generation sensors rely on direct electron transfer to the electrode [174]

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In addition to small molecule antioxidants, traditional Chinese medicinal formulations have been widely used in the treatment of cerebral I/R