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In Utero Supplementation with Methyl Donors Enhances Allergic Airway Disease in Mice

In wildtype mice, optogenetic inhibition of GABAergic interneurons in the medial prefrontal cortex (mPFC) leads to cognitive deficits ( +/ ) or absent (PV / ) expression exhibit the core ASD-like symptoms ( In addition, Reelin is an extracellular matrix glycoprotein closely related to neural development, which is involved in the regulation of neuronal migration, synaptic plasticity and neural network formation ( 3.2 The relationship between GABAergic signaling pathway abnormalities and ASD 3.2.1 The synthesis, release, transport, and metabolism of GABA The biosynthesis of GABA primarily relies on the decarboxylation of glutamate catalyzed by GAD

J Biol Chem 274, 12071215 (1999)

The optimal cutoffs were 10 days for treatment duration and 3.81 mg/L for trough VPC (Table 3)

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