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Mitochondrial dysfunction in bipolar disorder: evidence, pathophysiology and translational implications

For example, retinoid X receptor ( RXRG ) is targeted by gga-miR-140-5p, whereas sterol carrier protein 2 ( SCP2 ), acetyl-CoA acyltransferase 1 ( ACAA1 ), and acyl-CoA oxidase 1 ( ACOX1 ) are targeted by miR-15a to promote the differentiation of intramuscular preadipocytes, thereby increasing IMF deposition in muscle [78, 79]

Bergeron, S

Simultaneously, ALP, which generally maintains cellular homeostasis by degrading damaged organelles, is pathologically increased in CC, contributing to muscle atrophy through the degradation of both fiber proteins and organelles (Sandri, 2013)