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Bibcode:2007WeedT..21..279A

Abu AboudOChenCHSenapedisWBalogluEArguetaCWeissRH

Persistent increase in oxygen consumption and impaired neurovascular coupling after spreading depression in rat neocortex

462 These studies highlight the importance of rejuvenating the aged immune system for a healthy lifespan and for the treatment of neurodegenerative diseases

Mathematical Framework for Human Equivalent Dose The human equivalent dose (HED) formula is: HED (mg/kg) = Animal dose (mg/kg) (Animal Km / Human Km) Standard Km constants used in pharmacological scaling are: Rat Km = 6 Human Km = 37 To illustrate: If a rat study administers 10 mcg/kg, convert micrograms to milligrams: 10 mcg = 0.01 mg HED = 0.01 (6 / 37) HED 0.00162 mg/kg HED 1.62 mcg/kg For a 70 kg individual: 70 1.62 mcg 113 mcg This represents a mathematically scaled equivalent exposurenot a prescription