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Recent epidemiological studies on humans and experimental models in diabetes, cancer and cardiovascular diseases have demonstrated that regular use of ASA alone or as an adjuvant may improve the outcome of disease prevention/protection in favor of benefit: risk ratio [11]

It is therefore timely to organize these newly developed concepts and provide a solid background for further research

The therapeutic efficacy is dramatically hindered by complex pleiotropy, redundancy, toxicity, off-target effect, short half-life and narrow therapeutic window of cytokines (214)