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TPMT activity correlates inversely with 6-TGN levels in erythrocytes and presumably other hematopoietic tissues, since these cells have negligible xanthine oxidase (involved in the other inactivation pathway) activities

In summary, the VpreB-UR is involved in the interaction with V H and the nature of the V H domain seems to play an important role concerning the magnitude of the effect

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doi: 10.1016/j.immuni.2008.05.007 35 MaruyamaTLiJVaqueJPKonkelJEWangWZhangBet al