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Paralleling the emerging role of ferroptosis in fungal infections, ferroptosis has also been implicated in parasitic infections, where parasites exploit host iron metabolism and lipid peroxidation pathways to modulate cell death

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16, 21 Therefore, we have undertaken extensive studies to determine the potential for BSO to enhance the anti-myeloma activity of L-PAM at clinically achievable doses using in vitro (cell lines and fresh MM explants) and in vivo MM xenografts to determine if BSO+L-PAM warrants clinical trials in MM

Research has revealed that the complex modulates the expression of over 4,000 mammalian genes, with particularly pronounced effects on genes involved in tissue repair, antioxidant defense, and inflammatory resolution

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