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We then treated these cells with a low dosage of erastin, the inhibitor of cysteine transporter xCT 38 , which drastically reduced GSH level and induced replication stress (Fig.7f, g)

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Zangeneh MM (2020) Green synthesis and formulation a modern chemotherapeutic drug of Spinacia oleracea L

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In summary, our analyses using the 2D dermal fibroblasts and 3D reconstructed skin models support the idea that MB is a safe and potent anti-oxidant, and has great potential to be used in skin care