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doi: 10.1097/IMNA-D-23-00024

Indeed, it is known that hydrochlorothiazide can target several ion transporters and enzymes including SLC4A8 , a Na + -dependent Cl /HCO 3 exchanger (NDCBE), SLC26A4 , a Na + -independent Cl /HCO 3 exchanger (Pendrin) and carbonic anhydrases (Pickkers et al., 1999

Results Summary: While early Phase 2 trials showed promising functional improvements (EX: increased distance walked in the 6 minute walk test in PMM patients), large Phase 3 trials have been complex and have sometimes failed to meet primary endpoints, underscoring the challenge of treating complex mitochondrial disorders

Join Second Opinion Media's upcoming webinar tomorrow unpacking all of this and more with Rekha Kumar, M.D, M.S. Shared by Christina Farr Experience Chief Executive Officer Second Opinion Media Investor and Co-Founder Scrub Capital Manatt, Phelps & Phillips, LLP National Advisor Manatt, Phelps & Phillips, LLP Managing Director Manatt, Phelps & Phillips, LLP Co-Chair, Fortune Brainstorm Health Fortune Principal Investor, Health-Tech Lead OMERS Ventures Health and tech reporter CNBC Board Member San Francisco Classical Voice Senior Writer Fast Company Technology correspondent Thomson Reuters Investigative technology reporter VentureBeat Education Stanford University M.A

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