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Description

The amounts of serum AGEs are also higher in HCC than in NASH and healthy liver specimens

These parallel pro-death pathways collectively enable p53 to effectively induce ferroptosis, fulfilling its tumor-suppressive function

Additionally, EPO modulates the activity of anti-eryptotic kinases (e.g., AMP-activated protein kinase, AMPK) to maintain erythrocyte membrane integrity (Fller et al., 2009b