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Disclosures: Monica Tincopa: Nothing to Disclose, Lisa Richards: Nothing to Disclose, Rohit Loomba: Eli Lilly and Company: Consultant 1190 REPRESENTATION OF SEX, RACE AND ETHNICITY IN MASH TRIALS: A SYSTEMATIC REVIEW AND META-ANALYSIS Matheus Souza 1 Lubna Sharif 2 Ivanna Diaz 3 Samira Khalil 4 Xiu-He Lv 5 Alessandro Mantovani 6 Cristiane Villela-Nogueira, 1 School of Medicine, Federal University of Rio de Janeiro, 2 An-Najah National University, Nablus, Palestine, 3 SUNY Downstate Health Sciences University, Brooklyn, NY, United Sta, 4 Universidad de Buenos Aires, Buenos Aires, Argentina, 5 Sichuan University West China Hospital, Sinchuan, China, 6 University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy, Background: Despite efforts by National Institutes of Health and the US Food and Drug Administration to promote diverse participation in trials, randomized controlled trials (RCTs) in several areas have historically underrepresented female, racial and ethnic minorities

Here, we will (a) examine approaches to elucidate the GCN2methionineROS circuit to determine what forms of therapeutic modulation for T cell immunotherapies may be beneficial in a given context, and (b) explore different nodes within the GCN2-methionine-ROS circuit where intervention may be advantageous

Substantial evidence suggests that a late-night carbohydrate snack can counteract overnight catabolism [31]

Molecules 26:4887 Nilsson I, Palmer J, Apostolou E et al (2020) Metabolic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome not due to anti-mitochondrial antibodies