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National Center for Complementary and Integrative Health notes that randomized, placebo-controlled trials are the gold standard because they help determine whether apparent improvement is due to the treatment or to chance

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Bacteriostatic water also can't be used for IV administration without an isotonic admixture, because plain bacteriostatic water without a solute is hypotonic and can cause hemolysis on IV push

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What they found (summary): Amylin is a critical partner of insulin in metabolism, the loss of amylin in T2DM is as significant as the loss of insulin The AMY1 receptor in the area postrema is the primary target for the appetite effect Amyloid aggregation is the main problem with native amylin, proline substitutions (the Pramlintide strategy) are essential The half-life of native amylin is only 13 minutes, that is why lipidated analogs like Cagrilintide are necessary Perspective: amylin + GLP-1 combinations are the natural evolution of metabolic pharmacotherapy Why it matters: This is the reference article for amylin pharmacology