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Acknowledgements The authors want to thank the management of Saveetha College of Pharmacy, Saveetha a Institute of Medical and Technical sciences(SIMATS), Chennai, India for providing the library facility for this study

The advanced-aged mice experiment involved two groups of approximately 2527-month-old male C57BL/6 J mice

Furthermore, recent studies in both laboratory animals and humans increasingly sug-gest that moderate hyperhomocysteinemia impairs endothelial-dependent vasodilation (Bellamy et al, 1999