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Third, when FDA finally began to issue MDOs for flavored e-cigarette products, companies introduced synthetic nicotine products in a wide variety of flavors in a transparent effort to evade FDA regulatory authority altogether, which under the TCA applied only to products with tobacco-derived nicotine

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[8] [9] [10] [12] The Spanish introduced tobacco to Europeans in about 1528, and by 1533, Diego Columbus mentioned a tobacco merchant of Lisbon in his will, showing how quickly the traffic had sprung up