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3 Mutations and epigenetic alterations in normal-appearing tissues and their association with cancer risk Both mutations and epigenetic alterations are now known to be present even in normal-appearing tissues, and are likely to play a crucial role in predisposing cells to malignancies

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Between 2007 and 2011, Chinas smoking-induced LC period RRs generally exhibited a downward trend in both DALYs and death rates