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Researchers at Johns Hopkins University, who looked at the smoking habits of more than 300,000 adults for almost 20 years, found that men and women who smoked as few as two cigarettes daily had a 60% increased risk of death from any cause compared to those who never smoked

Oncogene 21 , 73497364 (2002)

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There were no differences in cigarette smoke induced emphysema, the severity of small airway remodeling, and the numbers of tissue macrophages and neutrophils and levels of 8-hydroxyguanosine between young and old mice

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