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Results showed that nicotine is not responsible for the effects of tobacco smoke on these isoenzymes ( Beyond PAHs and nicotine, other substances such as acetone, pyridine, heavy metals, benzene, and CO in tobacco smoke may also interact with hepatic enzymes, albeit their impact is considered less significant ( 4 Effects of tobacco smoke on metabolism of antidiabetic medications The treatment options for type 2 diabetes mellitus (T2DM) include various drug classes such as sulfonylureas (SUs), glinides (or meglitinides), biguanides, thiazolidinediones (also known as glitazones), -glucosidase inhibitors, dipeptidyl peptidase-4 (DPP-4) inhibitors, glucagon-like peptide-1 (GLP-1) receptor agonists, and sodium-glucose linked transporter-2 (SGLT-2) inhibitors