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3 Increased morbidity and mortality associated with cigarette smoking leads to increased costs for persons who smoke cigarettes and their families, healthcare systems, and society

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In four-week-old male weanling C57BL/6J mice treated with 25 or 50 ppm of sodium arsenite and high-fat-diet (HFD) for 20 weeks resulted in an increased glucose intolerance and decreased insulin secretion in dose-dependent manner compared with mice only exposed to HFD ( Table 1 Comparison of arsenic exposure effects on the signs of MS between epidemiological studies and animal models

The authors concluded that long-term exposure to IQOS could be detrimental to pulmonary health 49

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