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Signs and symptoms of more serious medical conditions that may cause swollen lymph nodes may include: Fever Night sweats Weight loss Loss of appetite Abdominal pain Swelling of multiple lymph nodes or only an isolated one Localized red patches of the skin over the lymph nodes Hard lumps or masses felt under the skin in the area of the swollen lymph node Sore throat or runny nose Local infections (toothache, sore throat) From Cancer Resources Health Solutions From Our Sponsors When should I see the doctor for swollen lymph nodes