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(137) showed that testicular torsion caused severe DNA damage induced by oxidative stress, leading to markedly increased expression of Tp53 , p21 , cyclin D1 , Bax and Casp3 in a time-dependent manner, as well as a significant increase in the apoptosis index, resulting in deteriorated testicular tissue and decreased sperm count in murine testicular tissue within 8 hours after testicular torsion

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