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Yan C, Kim D, Aizawa T, Berk BC (2003) Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator

However, animal research has also found that estrogen enhances dopamine release in the striatum and nucleus accumbens in the absence of drug exposure [26]it is therefore possible that estradiol may attenuate smoking cravings and reward by enhancing basal dopamine transmission