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According to a study by the U.S

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Others may be using very high doses regularly. But there are risks either way: Some are associated with frequent use, and others with being a novice user

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The infographic above shows the estimated average annual number of smoking-attributable deaths in the United States during 2005 through 2009 by specific causes, as follows: Total: more than 480,000 deaths Lung cancer: 137,989 deaths Other cancers: 36,000 deaths Heart Disease: 158,750 deaths Chronic Obstructive Pulmonary Disease: 100,600 deaths Stroke: 15,300 deaths Other diagnoses: 31,681 deaths Poison Center Calls Involving E-Cigarettes The number of poison center calls involving e-cigarettes went from one call per month in September 2010 to 215 calls per month in February 2014