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The study's sample size was calculated using Taro Yamane's formula [12], which is represented as follows: Here, n represents the desired sample size, N is the total population (5,537 in this case), and e stands for the level of precision, margin, or sampling error (in this case, assumed as 0.05, which is equivalent to a 5% margin) at a 95% confidence level

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Logistic regression analysis found that only smoking and the concomitant use of immunomodulators were independent predictors of response to one single infusion of the drug

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