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In addition, they also observed that human plasma MAO-A activity was positively correlated with BQ exposure in a cohort of 1,307 Taiwanese aborigines, with genetically predisposed individuals carrying the risk alleles of MAO-A exhibiting lower, albeit statistically non-significant levels of MAO-A ( Thus, it is likely that chronic and simultaneous exposure to BN, may develop selective tolerance (neuroadaptation) which perpetuate cycles of dependency ( MAO-A inhibitors have been reported to reduce the severity of BQ addiction and the amount of BQ consumed ( MAO-A in BQ addiction ( MAO-A gene were found to be predisposed to heavy BQ use ( MAO-A gene was reported to determine addiction severity through its effects on neurotransmitter metabolism, particularly dopamine and serotonin, which play vital functions in the regulation of mood and reward circuits ( While MAO-A inhibition provides a mechanistic link, it is unlikely to fully explain the heightened dependence observed in the combined users of BQ and tobacco

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