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One study found that seminal levels of folate were inversely correlated with sperm DNA fragmentation meaning that the lower the folate levels, the higher the number of sperm with genetic damage

A nootropic that is legal to buy in one country may still be blocked, seized, or require approval in another country if it is classified as a drug, therapeutic good, or restricted substance

Hofer, T., Wenger, R

Rare adverse events that might emerge in large systematic studies could remain invisible in informal self-experimentation

For instance, subcortical lacunar infarcts double the risk of PSCI, and when accompanied by severe WMHs, the risk increases 11-fold