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Conclusion: PHEGAESUS presents a novel PGAS-based approach to obtain mechanistic insights and to enable personalised approaches in diagnosis and treatment of ischaemic stroke by integrating genetic and phenotypic data and circulating biomarkers

Promotion of melanin synthesis by natural products and their derivatives Melanocytes are responsible for synthesising melanin, including eumelanin (brown to black) and pheomelanin (yellow to reddish-brown), and transferring it to the surrounding pre-cortical keratinocytes, and incorporating it into the growing hair shafts [210, 224]

However, the clinical translation of these findings remains constrained by significant methodological heterogeneity across studies

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Summary Keywords amodiaquine, quinoneimine, cytotoxicity, endoplasmic reticulum stress, human glutathione S -transferases P1 Citation Zhang Y, den Braver-Sewradj SP, den Braver MW, Hiemstra S, Vermeulen NPE, van de Water B, Commandeur JNM and Vos JC (2018) Glutathione S -Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells