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Further studies have found that MIF, as a determinant factor of ROS production after vascular endothelial cells were exposed to CS, affected the apoptosis signal-regulating kinase 1 (ASK1) P38 kinase cascade, regulated the activity of XOR enzymes produced by ROS and antagonized ASK1-p38-dependent pulmonary vascular endothelial cell apoptosis

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People can get hepatitis A if they ingest contaminated food or water, eat foods prepared by an infectious person, or if they have close physical contact (such as oral-anal sex) with an infectious person, although casual contact among people does not spread the virus

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