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Because the Agency found the necessary, product-specific evidence absent in each of these applications, the FDA issued MDOs

To avoid randomized non-starters and potential bias due to differential early attrition from prior knowledge of group assignment, randomization will occur at the time of visit 0 when participants first receive tobacco products specific to their assigned condition, and neither the research assistant nor participant will know the assignment in advance

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Passing a new tax under a Republican-controlled House and Senate is a difficult task

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