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In 2020, these figures rose to 38% of smokers (2.4 million people) reporting high anxiety and 21% (1.3 million people) reporting low levels of happiness compared with 34% and 12% of non-smokers respectively

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[44] In a study examining the association between perceived tobacco dependence and smoking susceptibility among adolescent who were minimal smokers, perceived mental dependence on tobacco, and not perceived physical dependence, was associated with smoking susceptibility

What I think is that Van Goghs skeleton smoking is a portrayal of the artists condition and sufferings at that time