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Carbon monoxide in the smoke combines with hemoglobin to form carboxyhemoglobin, impairing the oxygen-carrying capacity of red blood cells and causing tissue hypoxia, which can induce coronary artery spasm

Smokeless tobacco is responsible for up to 500,000 deaths each year

Acknowledgements This research was completed using data collected through the 45 and Up Study (www.saxinstitute.org.au)

The microRNA miR-22 inhibits the histone deacetylase HDAC4 to promote T(H)17 cell-dependent emphysema

A: The water does absorb some of the nicotine, but water pipe smokers can nonetheless be exposed to sufficient amounts to cause addiction