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These can include: a weakened immune system because of illness or stress hormone changes, such as menstruation a vitamin deficiency, especially of folate and B12 intestinal issues, such as Crohns disease or ulcerative colitis, both types of inflammatory bowel syndrome (IBS) exposure to toxins in drinking water emotional or psychological stress smoking or a history of smoking Cold sores Cold sores look like fluid-filled blisters that appear near the mouth and lips

The most thorough review of the research yet, from the National Academies of Sciences, Engineering, and Medicine, found that pot poses a variety of possible downsides including respiratory problems if smoked, schizophrenia and psychosis, car crashes, general social achievement in life, and potentially babies in the womb