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The fact that i) these 8 patients were diagnosed years ago [12], ii) none of them originally experienced major vascular events (1 individual with the COL1A1 variant showed aortic ectasia, uncomplicated tortuous vertebral arteries, and left ventricular thickening), and iii) all underwent periodical vascular surveillance that resulted negative at the time of writing, suggests that the supposed genotype-phenotype correlations of these variants should not be considered valid in all cases

Written by Gregory David Roberts, a convicted bank robber and heroin addict who escaped from an Australian prison and resurfaced in 1980s Bombay, its been on Hollywoods must-make list ever since its 2003 publication

law mandated health warnings on printed cigarette packaging boxes, marking a significant regulatory move

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