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Irritability : Increased frustration or anger as a result of the sudden drop in nicotine, which affects mood-regulating neurotransmitters in the brain

Modulating KMO gene expression could be a useful tactic for the treatment of tobacco dependence ( KMO is reduced in schizophrenia and in bipolar patients with a history of psychosis ( KMO SNPs were found frequently in schizophrenia patients compared with healthy controls ( Integrated bioinformatics approaches were used to show the differentially expressed genes (DEGs) in smokers and non-smokers

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We subtracted deaths from smoking-attributable causes, opioid poisoning, cirrhosis and external causes from the total mortality in each age-, sex- and education-specific stratum to determine deaths from all other causes