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Group-customized (RR 1.98, 95% CI 1.043.75), interactive (RR 1.92, 95% CI 1.342.76) and standard interventions (RR 1.74, 95% CI 1.222.61) also significantly improved quit success

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Nicotine activates, saturates and desensitizes dopamine pathway receptors, which is followed by growth or activation of millions of extra receptors, a process known as up-regulation