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Phase I modifications, which include oxidation, reduction, hydrolysis, cyclization/decyclization and removal of hydrogen or addition of oxygen to more polar molecules, result in changes in the chemical structure of the lipophilic drug

What caused the growth and later decline of smoking in traditional markets

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Its molecular structure has some similarity to that of nicotine and varenicline, and it has the same pharmacological effects: it is a partial agonist of brain nicotinic acetylcholine receptors

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