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We defined a perturbation strength ( PS ) as the percentage change of a kinetic parameter value to the perturbation of a system component (e.g., T or E3 ) as follows: where perturbed ( p i ) and nominal ( p i ) are perturbed and nominal value of parameter p i , respectively

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Nicotine per se doesn't cause cancer, it is the poly cyclic aromatic hydrocarbons in the smoke (produced when a cigarette is lit) that is carcinogenic and stimulates other carcinogenic reactions," comments P K Julka, professor, department of radiology and oncology, All India Institute of Medical Sciences, Delhi

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