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27,28 Genetic polymorphisms in the genes responsible for ion channels, neurotransmitter receptors, and metabolic enzymes that are involved in the metabolism of nicotine and e-liquid may also affect the likelihood of developing seizures after using e-cigarettes

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Longitudinal studies are also needed to establish causal and temporal relationships between seizures and e-cigarette usage as users will be monitored over time to assess the incidence of seizures, to account for bias and confounding influences, and to take into account changes in e-cigarette use patterns or devices

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