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To enhance the translational relevance of animal studies, future research should emphasize the use of humanized gnotobiotic models, which are colonized with microbiota derived from well-characterized cohorts of smokers and nonsmokers

Under different conditions, M2-like macrophages further differentiate into three subtypes that function at every stage of the metastatic cascade, these subtypes consist of M2a, M2b, and M2c

Many antibiotics also have serious side effects when taken chronically, and prolonged use might encourage growth of bacteria resistant to these drugs