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[PubMed: 17130387] Gidding SS, Xie X, Liu K, Manolio T, Flack JM, Gardin JM

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Nicotine triggers a chemical stress response, ramping up hormones like cortisol and adrenaline

This enabled us to investigate the effects on endothelial cells of substances in smoke/aerosol that are absorbed through the lungs and enter the bloodstream, and also any other circulating molecules that the body might produce in response to inhaling the smoke and/or aerosol, including proteins involved in the inflammatory response. The study included 120 adults, ages 21-50 years without cardiovascular disease