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In this respect it could be said that the directors and executives of tobacco companies do not intend to cause their customers to suffer, nor do they need the suffering, injury, and death of their customers to achieve their goalsthese consequences are merely an incidental result of their marketing activities

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This transition suggests that prolonged exposure within a three-dimensional epithelial context recapitulates mutational processes characteristic of smoking-related lung cancers, emphasizing that the tissue-level environment facilitates the emergence of canonical tobacco-associated genomic patterns

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