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The chemicals taken in from cigarettes can also inhibit immune system function and lead to many types of cancer and other diseases, including: Aortic aneurysm Aortic aneurysm Cancers, including lung, esophageal, larynx, mouth, throat, kidney, liver, bladder, and pancreatic cancer Chronic obstructive pulmonary disease Diabetes Osteoporosis Rheumatoid arthritis For these reasons, smoking is the number one cause of early, preventable death in the United States