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have demonstrated that the intra-arterial infusion of epinephrine and nicotine in rabbits resulted in reduced gingival blood flow rates in spite of increased systemic perfusion pressure.[20] Smokers who underwent periodontal surgery with either modified Widman flap or mucoperiosteal flap reflection had significantly less reduction in the pocket depth and gain in clinical attachment levels compared with nonsmokers

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Development of antibodies against cytomegalovirus, varicella-zoster virus and herpes simplex virus in Finland during the first eight years of life: a prospective study

Reason holds no power here