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These canker sores: Are pinpoint size Often occur in clusters of 10 to 100 sores, but may merge into one large ulcer Have irregular edges Heal without scarring in one to two weeks When to see a doctor Consult your doctor if you experience: Unusually large canker sores Recurring sores, with new ones developing before old ones heal, or frequent outbreaks Persistent sores, lasting two weeks or more Sores that extend into the lips themselves (vermilion border) Pain that you can't control with self-care measures Extreme difficulty eating or drinking High fever along with canker sores See your dentist if you have sharp tooth surfaces or dental appliances that seem to trigger the sores

For pure hand-rolled cigarettes, the risk decreased slowly as average daily consumption increased (Figure 1B)

For more detailed phenotypic information, please refer to Supplementary file Table S3