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Medical Complications: Amphetamines Pregnancy limited human data confounded by exposure to other drugs suggestion of increased rates of premature delivery placental abruption fetal growth retardation heart and brain abnormalities Medical Complications: Barbiturates Sedative-hypnotics, includes pentobarbital, secobarbital, phenobarbital, thiopental Complications relate to the inhibition of neuronal depolarization potentiating, prolonging, and mimicking GABA, the inhibitory neurotransmitter blocking glutamate receptors Medical Complications: Barbiturates Acute toxicity: narrow therapeutic index small increment in dose can yield toxicity depression of the respiratory drive(s) - neurogenic and hypoxemic Chronic toxicity: tolerance

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