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The FDA noted that Among several key considerations, the agencys evaluation showed that, due to substantially lower amounts of harmful constituents than cigarettes and most smokeless tobacco products, such as moist snuff and snus, the authorized products pose lower risk of cancer and other serious health conditions than such products. The FDA also stated, In addition, based on evidence suggesting the potential for reduction in lung cancer risk following significant reduction in cigarettes per day, the new products may also pose a benefit to adults who switch and significantly reduce their cigarette use. Based on the totality of evidence available, fully switching to nicotine pouches is deemed less harmful than smoking cigarettes

This is due to the significantly lower levels of toxicants in e-cigarette vapour compared to cigarette smoke

Ingredients: Wafer: Enriched wheat flour, Sugar, Nonfat dry milk powder, Butter (cream, milk, natural flavor), Egg yolks, Salt, Sunflower lecithin, Natural flavors

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In subgroup analyses of change in body weight and blood sample values, linear regression was used to calculate the change between the run-in period, week 4 and week 12 for participants using nicotine vs tobacco pouches during the run-in period