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Comparison of serum and salivary cotinine measurements by a sensitive high-performance liquid chromatography tandem mass spectrometry method as an indicator of exposure to tobacco smoke among smokers and nonsmokers

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The most abundant aromatic compounds in mainstream smoke generated from full-flavored cigarettes with use of the FTC/ISO smoking regimen are toluene (approximately 5 to 80 g generated per cigarette), benzene (approximately 4 to 60 g), total xylenes (approximately 2 to 20 g), styrene (approximately 0.5 to 10 g), and ethylbenzene (approximately 1 to 8 g) (Counts et al

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