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The abundant remains of Bufo marinus at San Lorenzo, for example, suggest that the Olmecs sought the hallucinogenic effects of eating these toads.15 Coe and other students of the Classic period Maya have found extensive evidence on painted ceramics of the practice of ritual hallucinogenic enemas, a practice that seems to have roots in the Preclassic.16 Furthermore, "the presence of mushroom stones and associated manos and metates in Middle and Late Preclassic caches and tombs indicates the existence of a widespread mushroom cult similar in concept, but not necessarily in performance, to that known [today] among the Mixtecs, Zapotecs, and Mixes of Oaxaca."17 This fragmentary evidence of the shamanic use of hallucinogens in pre-Columbian Mesoamerica takes on its proper significance when we examine the use of hallucinogens among the Aztecs