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Adult and adolescent rats of both sexes (n = 5-7/group) were exposed to either nicotine (JUUL, 5% nicotine) or vehicle vapour for 10 minutes and then assessed for either conditioned place preference (3 exposures paired with CPP chamber) or withdrawal (3x a day for 2 weeks)

Studies have also characterized a PNE mouse model that displays the full range of ADHD associated behavioral phenotypes including attention deficit and impulsive-like behavior and working memory deficits [82]